Treatment of toxic epidermal necrolysis (TEN) with low dose intravenous immunoglobulin in child.

J Coll Physicians Surg Pak. 2010 Mar;20(3):205-7.

Habib A, Pasha W, Raza N.

Department of Dermatology, Combined Military Hospital, Pano Aqil Cantt.


Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN, Lyell's disease) are severe, episodic, acute mucocutaneous reaction that may be caused by various factors particularly drugs. Treatment is primarily supportive care and there are no specific therapy regimens. Intravenous immunoglobulin (IVIG) has recently been shown to be a useful and safe therapy in paediatric patients with SJS/TEN, though no such case has so far been reported from Pakistan. The authors report the experience with low dose IVIG (0.1 g/kg/day for four consecutive days for treating a 3 years old boy with toxic epidermal necrolysis with favourable outcome without early complications.

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