Immunoglobulin deficiencies: the B-lymphocyte side of DiGeorge Syndrome.

J Pediatr. 2012 Nov;161(5):950-3. doi: 10.1016/j.jpeds.2012.06.018. Epub 2012 Jul 17.
Immunoglobulin deficiencies: the B-lymphocyte side of DiGeorge Syndrome.
Patel K, Akhter J, Kobrynski L, Benjamin Gathmann MA, Davis O, Sullivan KE; International DiGeorge Syndrome Immunodeficiency Consortium.
Collaborators (41)
Source

Division of Allergy Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Erratum in

    J Pediatr. 2013 Mar;162(3):658. Gathman, Benjamin [corrected to Benjamin Gathmann, M A].

Abstract

DiGeorge syndrome is associated with a T-lymphocyte immunodeficiency. The prevalence of hypogammaglobulinemia has not been reported. We found that 3% of patients with DiGeorge syndrome were receiving immunoglobulin replacement therapy and 6% of patients over the age of 3 years had hypogammaglobulinemia. We conclude that DiGeorge syndrome is associated with significant humoral immune deficiency.

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