Hematology

Two-step immunoablative treatment with autologous peripheral blood CD34(+) cell transplantation in an 8-year-old boy with autoimmune haemolytic anaemia.

Br J Haematol. 2000 Sep;110(4):900-2.  
 
Paillard C, Kanold J, Halle P, Yakouben K, Boiret N, Rapatel C, Berger M, Malpuech G, Demeocq F.

Unite Bioclinique de Therapie Cellulaire et de Transplantation Medullaire, Pediatrie B, CHU Clermont-Ferrand, France. paillard@usa.net

Life-threatening haemolysis in children with autoimmune haemolytic anaemia (AIHA) occurs rarely. Many cases of severe autoimmune disease are currently treated with immunosuppressive high-dose chemotherapy and autograft. We report here a case of a child with severe AIHA who did not respond to conventional treatments, but was cured with an autologous peripheral blood CD34(+) cell transplantation. After d 16 post autograft, no further red cell transfusions were required. At 20 months post autograft, haematological complete remission persists.

Publication Types:
  • Case Reports

PMID: 11054079 [PubMed - indexed for MEDLINE]
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