Experience with immunomodulatory treatments in Rasmussen's encephalitis.


Neurology. 2003 Dec 23;61(12):1807-10.  

Granata T, Fusco L, Gobbi G, Freri E, Ragona F, Broggi G, Mantegazza R, Giordano L, Villani F, Capovilla G, Vigevano F, Bernardina BD, Spreafico R, Antozzi C.

Division of Child Neurology, Istituto Nazionale Neurologico C. Besta, Milan, Italy. granata@istituto-besta.it

The authors investigated immunomodulatory treatments in 15 patients with Rasmussen encephalitis (RE) (14 with childhood and one with adolescent onset RE). Positive time-limited responses were obtained in 11 patients using variable combinations of corticosteroids, apheresis, and high-dose IV immunoglobulins. Although surgical exclusion of the affected hemisphere is the only treatment that halts disease progression, immunomodulation can be considered when early surgery is not feasible, in late-onset patients with slower disease progression, and in the few cases of bilateral disease.

PMID: 14694056 [PubMed - indexed for MEDLINE]
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