[High doses of immunoglobulin G in the therapy for severe forms of myasthenia gravis and Guillain-Barre syndrome]

Vojnosanit Pregl. 2006 Jan;63(1):37-42.

[Article in Serbian]

Lavrnic D, Romic M, Kacar A, Stojanovic-Rakocevic V, Stevic Z, Vujic A, Basta I, Marjanovic I, Bogdanovic G, Apostolski S.

Klinicki centar Srbije, Institut za neurologiju, Beograd.

BACKGROUND/AIM: High doses of immunoglobulin G (IVIG) have been recognized as a very important therapeutic modality in the treatment of neurological diseases. The aim of this report was to present our experience in the treatment of severe forms of myasthenia gravis (MG) and Guillain-Barre syndrome (GBS).

METHODS: We analyzed the efficacy and safety of immunoglobulin G therapy in 53 patients with severe forms of myasthenia gravis, and 27 patients with very severe forms of Guillain-Barre syndrome. RESULTS: At the end of the follow-up period, a significant improvement was noticed in 47 out of 53 patients with myasthenia gravis (88.7%). In the group of 27 patients with severe forms of Guillain-Barre syndrome an improvement was registered in 19 patients (70.3%). The side effects of this therapy were mostly mild, manifested as headache, myalgia, skin rash, adynamia, and other clinically insignificant effects. No severe side effects were recognized. CONCLUSIONS: Our study clearly demonstrated the high efficacy of IVIG therapy in the treatment of severe forms of myastehnia gravis and Guillain-Barre syndome.

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