Intravenous immunoglobulins in severe Guillian-Barre syndrome in childhood.


Indian J Pediatr. 2003 Jul;70(7):541-3.  

Shanbag P, Amirtharaj C, Pathak A.

Department of Pediatrics, Lokmanya Tilak Municipal Medical College & General Hospital, Sion, Mumbai, India.

OBJECTIVE: This is a retrospective analysis of 25 children with severe Guillain-Barre syndrome admitted to our PICU. METHOD: All children were treated with intravenous immunoglobulins (IVIG) in a dose of 2 g/kg body weight over 2-5 days in addition to supportive and respiratory care. Seventeen children were elective admissions to the PICU whereas 8 children were transferred from other hospitals in a critical condition. Five of 8 of the late referrals died as compared to none of the elective admissions. RESULT: All 8 of the late referrals required mechanical ventilation as against 3 of the 17 elective admissions. Mean duration of PICU stay in the late referrals was 27 days as compared to 15 days in the elective admissions. CONCLUSION: The authors concur with previously published reports, that early use of IVIG could reduce the mortality and the need for intubation and mechanical ventilation.

PMID: 12940374 [PubMed - indexed for MEDLINE]
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