Neurology

What's new in multifocal motor neuropathy in 2007-2008?

J Peripher Nerv Syst. 2008 Dec;13(4):261-3.

Nobile-Orazio E.

Department of Neurological Sciences, Milan University, 2nd Neurology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy. eduardo.nobile@unimi.it

Several articles on multifocal motor neuropathy (MMN) have appeared in 2007 and 2008, broadening the boundaries of this neuropathy and improving its diagnosis. A number of retrospective studies confirmed the prolonged efficacy of high-dose intravenous immunoglobulins (IVIg) in this neuropathy. The efficacy of other immune therapies was not however, confirmed in other studies in MMN including a randomized controlled trial on mycophenolate mofetil as adjunctive therapy to IVIg. These negative results and the lack of new other studies on the cause of MMN should lead to some reconsideration on its pathogenesis.

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