Neurology

[A comparative study of intravenous immunoglobulin and plasmapheresis preoperatively in myasthenia]

Rev Neurol. 2001 Sep 1-15;33(5):413-6.
 
[Article in Spanish]

Perez Nellar J, Dominguez AM, Llorens-Figueroa JA, Ferra-Betancourt A, Pardo A, Quiala M, Gali Z.

Servicio de Neurologia, Hospital Clinico Quirurgico Hermanos Ameijeiras, La Habana, 10300, Cuba. jpnellar@yahoo.com

INTRODUCTION: Thymectomy is a well established procedure in myasthenia gravis (MG). To reduce its morbidity, treatments which are effective in the short term, such as plasmapheresis and intravenous immunoglobulin (IGI) have been used. OBJECTIVE: To evaluate the efficacy and tolerability of the IGI, compared with plasmapheresis, in the preparation of myasthenic patients before thymectomy. PATIENTS AND METHODS: We compared a group of 33 prospective myasthenic patients treated with IGI with 38 clinical histories taken as controls treated by plasmapheresis during the peri operative period of thymectomy. RESULTS: The patients treated with IGI were in the intensive care unit and neurology ward for less time. The endotracheal tube was also removed sooner. However, these differences were not significant. The commonest complications of IGI were fever, shivering and phlebitis. The most frequent adverse reaction to plasmapheresis were cutaneous eruptions. One patient developed Hepatitis C after plasmapheresis. CONCLUSION: IGI is comparable in efficacy to plasmapheresis in the peri operative period of MG, but has a better profile of adverse reactions.

Publication Types:
  • Clinical Trial
  • Controlled Clinical Trial

PMID: 11727205 [PubMed - indexed for MEDLINE]
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